The only arthritis cream with Wogonin · Made in USA · FDA compliant

Finally. A cream that targets the source of your joint pain — not just the feeling.

Arthritis Wonder is the result of 12+ years of osteoarthritis research. Its patent-pending formula with natural Wogonin penetrates through the skin to block pain and inflammation at the joint itself.

🚚

Free shipping when you order 2 or more tubes. Most customers use 1 tube per month — stock up and never run out mid-treatment.

Get Arthritis Wonder — Free Shipping on 2+ 100% Money-Back Guarantee · No time limit · No hassle See bundle options ↓
★★★★★ 4.3 · 1,300+ verified Amazon customers
Non-greasy Fast acting HSA/FSA eligible
Arthritis Wonder Pain Relieving Cream
12+ yrs
OA research
Wogonin
Only cream with it
5 min
To feel relief
🚚 Free
Shipping on 2+ tubes
Does this sound like you?

Osteoarthritis doesn't just hurt.
It takes things from you.

The stiffness, the swelling, the pain that comes back every single morning. If you've been told to just "manage it" — you deserve better than that.

Person experiencing joint pain in hands
Customer reviews

Real words from real customers.

★★★★☆ 4.3 · 1,300+ verified Amazon customers
✓ Genuine reviews from WonderPainRelief.com, Amazon, eBay, and Reviews.io. Lifestyle photos are illustrative — not attached to specific reviewers.
KH
Karyl Howard ✓ Verified
June 2019 · WonderPainRelief.com
★★★★★

"This cream has been life changing for me, someone who lives in a cold climate during the winter time. The pain has been drastically reduced to the point that I can actually go for a walk outside and not fear the aches and pain that would come after. I'm able to do more with my family and friends."

MB
M.B. ✓ Verified
WonderPainRelief.com
★★★★★

"Every pain that I have put the cream on is now pain-free... and it happened almost immediately!!! It's like NOTHING ELSE that I have ever tried!!!! This cream will be a true blessing to SO many people!!!!"

RJ
R.J. ✓ Verified
eBay · Verified purchase
★★★★★

"I've been using this for my knees, lower back, and shoulder pain and it really works quickly. Smells nice, not overpowering, and doesn't feel greasy. When I apply this cream the pain seems to disappear."

LC
L.C. — Medical clinic ✓ Verified
Reviews.io
★★★★★

"I work in a medical clinic and have had several patients try Arthritis Wonder — only positive feedback. One lady tried a sample, walked to the door, turned around and came back for 2 tubes. I feel confident recommending it to anyone with joint pain."

TP
T.P. ✓ Verified
WonderPainRelief.com
★★★★★

"I've had back pain for a long time. Arthritis Wonder is really helping my back. I have a lot of pain in the mornings so I use it at night and wake up with much less pain than I used to."

SK
S.K. ✓ Verified
WonderPainRelief.com
★★★★★

"No more knee and back pain. I can easily walk up and down the stairs with no more pain. I love Arthritis Wonder."

Active seniors biking outdoors
Get back to moving. Life doesn't stop — your pain should.
Couple gardening together
Do what you love again. Gardening, walking, playing with grandkids — it's all possible.
Natural herbal compounds including Skullcap — the source of Wogonin
The active ingredient

Wogonin. The only ingredient of its kind in any pain cream on the market.

Other creams use heat or cold to distract your brain from pain. That's temporary. Arthritis Wonder is built around Wogonin — a natural flavonoid extracted from the Skullcap herb, used in Chinese medicine for centuries and now studied extensively for its effect on osteoarthritic joints.

What the published research shows

Peer-reviewed studies demonstrate that Wogonin reduces key inflammatory markers in OA joints, inhibits the enzymes that break down cartilage (MMP-13, MMP-3, MMP-9), and protects cartilage tissue — not just numbing the pain.

Sources: Frontiers in Physiology (2020) · NIH/PMC (2017) · ScienceDirect (2025)

Proven to penetrate

Arthritis Wonder delivers 90% of its proprietary blend through the skin and directly to the affected joint. The Wogonin isn't sitting on your skin — it reaches where the inflammation actually lives.

How Wogonin works at the joint

1

Penetrates transdermally — validated by Dr. Kooyman's research team using pig ear skin in a Franz diffusion system, confirming Wogonin is delivered through skin directly to the affected joint. [1]

2

Targets TLR4 receptors — TLR4 is identified as a primary driver of OA joint inflammation; Wogonin has been shown to inhibit the TLR4-mediated signaling pathway, reducing inflammatory cascades at the source. [2]

3

Antioxidant action — Wogonin acts as a chondroprotective antioxidant, reducing oxidative stress in OA chondrocytes and slowing the cell death that leads to cartilage degradation. [3]

4

Protects cartilage — shown to inhibit matrix-degrading enzymes MMP-13, MMP-3, MMP-9, and ADAMTS-4 in human OA chondrocytes, protecting cartilage from breakdown. [4]

Patent-pending formula · 12+ years of OA research · Made in USA

References
[1] Smith, Starr, Goodman et al. & Kooyman DL (senior author & patent inventor). Topical Application of Wogonin Provides a Novel Treatment of Knee Osteoarthritis. Frontiers in Physiology, 2020. Dept. of Physiology & Developmental Biology, Brigham Young University. doi:10.3389/fphys.2020.00080
[2] Bartels et al. Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis. Rheumatology, 2024. doi:10.1093/rheumatology/kead493
[3] Khan et al. Wogonin exerts potent anti-inflammatory and chondroprotective effects through ROS/ERK/Nrf2 signaling in human OA chondrocytes. Free Radical Biology and Medicine, PMC, 2017. PMC5490997
[4] Khan et al. Wogonin inhibits MMP-13, MMP-3, MMP-9 and ADAMTS-4 in human OA chondrocytes. Osteoarthritis and Cartilage, 2017. doi:10.1016/j.joca.2017.02.794

The researcher behind the formula

He has osteoarthritis too.
That's why he spent 12+ years solving it.

DK
Dr. David L. Kooyman
Professor of Physiology & Developmental Biology · Brigham Young University · Patent inventor · OA sufferer
Read the study →
12+
Years of OA research at BYU
2,200+
Citations in scientific literature
Patent
Pending — US & International
Peer Reviewed
Reviewed, Frontiers in Physiology 2020
Choose your supply

Order 2 or more — shipping is free.

★★★★☆ 4.3 · 1,300+ verified Amazon customers

Results build with consistent daily use. Stock up so you never run out mid-treatment.

Arthritis Wonder Pain Relieving Cream 4oz tube
1 tube
30-day supply · 4oz
$18.99
$18.99 per tube
+ shipping
Add to cart
Best Value
3 tubes
90-day supply · 4oz each
$49.99
$16.66 per tube
✓ Free shipping included
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Our promise

100% satisfaction. No time limit. No fine print.

100%
Money Back

Love it — or it's free. No questions asked.

If you are less than 100% satisfied for any reason, call our US-based customer service at (800) 456-1395 and your refund will be processed quickly and respectfully. No time limit. No fine print. No forms. It really is that simple.

How to use it

Simple. Consistent. Effective.

1

Apply a coin-sized amount to the affected joint

Knees, hands, back, shoulders, ankles — apply directly where you feel pain. No need for more than a coin-sized amount per joint.

2

Massage until fully absorbed

Non-greasy formula absorbs quickly — no residue, no overpowering smell, no staining.

3

Use daily for 7–10 days, then as needed

Daily use builds Wogonin concentration in the joint. Most people feel relief within 5 minutes. The more consistently you use it, the better and longer lasting the results.

Person with mobile, pain-free hands outdoors
Questions

Straight answers.

What makes Arthritis Wonder different from other pain creams?
It's the only pain cream on the market formulated with Wogonin — a natural compound that targets TLR4 receptors in the joint to address inflammation at its source. Other creams use heat or cold to temporarily distract from pain. Arthritis Wonder is designed to actually reach the joint.
How long before I feel results?
Most customers feel relief within 5 minutes of applying. With consistent daily use over 7–10 days, results become longer lasting. The more consistently you use it, the more effective it becomes.
Which joints does it work on?
Hands, wrists, knees, ankles, shoulders, back, neck — anywhere you apply it. Many customers use it on multiple joints at once.
When do I get free shipping?
Free shipping applies automatically when you order 2 or more tubes. Single tube orders ship at standard rates.
What if it doesn't work for me?
You're covered by our 100% satisfaction guarantee with no time limit. Call (800) 456-1395 and we'll refund you — no questions, no fine print, no hassle.

Hurt less. Do more.
Start today.

You've been managing long enough. Arthritis Wonder gives your joints what they actually need — not just temporary relief.

★★★★☆ 4.3 · 1,300+ verified Amazon customers